Blar i forfatter "Lindin, Inger"

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    • Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5 

      Lindin, Inger; Wuxiuer, Yimingjiang; Sylte, Ingebrigt; Ravna, Aina Westrheim; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5) 

      Lindin, Inger; Wuxiuer, Yimingjiang; Kufareva, Irina; Abagyan, Ruben; Moens, Ugo; Sylte, Ingebrigt; Ravna, Aina Westrheim (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the groups of Houng Ni and Ligou New, and was found to be highly conserved throughout the vertebrates. Studies, both in vivo and in vitro, have shown that it is implicated in tumor ...

    • Mitogen-activated protein kinase-activated protein kinase 5 - Structure, function and inhibition 

      Lindin, Inger (Doctoral thesis; Doktorgradsavhandling, 2014-09-26)
      Protein kinases have become central in the efforts to understand the nature of various diseases, and a lot is invested into creating effective therapeutic strategies and finding effective and selective protein kinase inhibitors. In order to succeed it is also important to focus on the structure of the kinases, their exact biological role, and how they interact and cooperate in the signaling. The ...

    • The relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determines their cytotoxicity 

      Rekdal, Øystein; Haug, Bengt Erik; Kalaaji, manar; Hunter, Howard N.; Lindin, Inger; Israelsson, Ingrid; Solstad, Terese; Yang, Nannan; Brandl, Martin; Mantzilas, Dimitrios; Vogel, Hans J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-11-04)
      Background: Tryptophan side chains can influence the binding of amphipathic peptides to biological membranes. <p>Results: The cytotoxic activity of model helical amphipathic peptides was markedly influenced by the positions of tryptophan residues in the sequence. <p>Conclusion: Tryptophan residues located adjacent to a hydrophobic helical portion created the most potent cytotoxic peptides. <p> ...

    • Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells 

      Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Lindin, Inger; Rekdal, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mechanisms and have been shown to induce a protective immune response against solid tumors, thus making them interesting candidates for developing novel lead structures for anticancer treatment. ...